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First Kidney Regeneration Using Biological Scaffold Performed in WMU

DateTime:2015-03-30  

    A research team in the School of Basic Medical Science of WMU successfully induced kidney regeneration in rats with partially excised kidneys using decellularized biological scaffold. The study has been published on Biomaterials, with Associate Professor Jin Mei as the correspondent author, and Yaling Yu, a postgraduate student of WMU as the first author.
 

China has 120 million patients with renal disease, of which the irreversibility has plagued patients, doctors and medical researchers. The common understanding of the international research community was that kidney regeneration was not viable in vertebrate animals except in Zebra fish. The success of this research builds upon the fine preparation of decellularized renal scaffold, which contributes to the surface reparation process. The post-operation observation witnessed the growth of kidney, with radioactive nuclein detecting rising post-op glomeruli filtering rate, as well as a growing number of precursor cells with regular distribution in the kidney observed using immunology method.

 

Experts predict that this outcome would bring significant hope to patients with renal diseases, as well as galvanizing further research on this front. The research is independently conducted by WMU researchers, who have the intellectual property right. This also marks a landmark in the research of the field by School of Basic Medical Science of WMU.